Title: The tricks of the trait: Neural implementation of personality varies with genotype-dependent serotonin levels
Authors: Hahn, T. # ×
Heinzel, S. #
Notebaert, Karolien #
Dresler, T. #
Reif, A. #
Lesch, K.-P. #
Jakob, P.M. #
Windmann, S. #
Fallgatter, A.J. #
Issue Date: 2013
Publisher: Academic Press
Series Title: NeuroImage vol:81 pages:393-399
Abstract: Gray's Reinforcement Sensitivity Theory (RST) has developed
into one of the most prominent personality theories of the last decades. The RST postulates a Behavioral Inhibition System (BIS) modulating the reaction to stimuli indicating aversive events. A number of psychiatric disorders including depression, anxiety disorders, and psychosomatic
illnesses have been associated with extreme BIS responsiveness. In recent years, neuroimaging studies have implicated the amygdala-septohippocampal circuit as an important neural substrate of the BIS. However, the neurogenetic basis of the regulation of this behaviorally and clinically essential system remains unclear. Investigating the effects of two functional genetic polymorphisms (tryptophan hydroxylase-2, G-703T, and serotonin transporter, serotonin transporter gene-linked polymorphic region) in 89 human participants, we find significantly different patterns of associations between BIS scores and amygdala-hippocampus connectivity during loss anticipation for genotype groups regarding both
polymorphisms. Specifically, the correlation between amygdala-hippocampus connectivity and Gray's trait Anxiety scores is positive in individuals homozygous for the TPH2 G-allele, while carriers of at least one T-allele show a negative association. Likewise, individuals homozygous for the 5-HTTLPR LA variant display a positive association while carriers of the S/LG allele show a trend towards a negative association. Thus, we show converging evidence of different neural implementation of the BIS depending on genotype-dependent levels of serotonin. We provide evidence
suggesting that genotype-dependent serotonin levels and thus putative changes in the efficiency of serotonergic neurotransmission might not only alter brain activation levels directly, but more fundamentally impact the neural implementation of personality traits. We outline the
direct clinical implications arising from this finding and discuss the complex interplay of neural responses, genes and personality traits in this context.
ISSN: 1053-8119
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Centre for Marketing and Consumer Science, Leuven
× corresponding author
# (joint) last author

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