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Title: LC-MS/MS in forensic toxicology: what about matrix effects?
Authors: Verplaetse, Ruth ×
Tytgat, Jan #
Issue Date: Mar-2011
Series Title: TIAFT Bulletin vol:41 pages:8-16
Abstract: Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) is more and more used in forensic toxicology. This is a highly selective and sensitive technique, but can be negatively affected by matrix effects i.e. the influence of co-eluting compounds on the analyte of interest. The complex composition of forensic samples forces the researcher who is using LC-MS/MS to be aware of matrix effects, evaluate these and, if possible, eliminate these. Therefore, this review discusses the nature of forensic samples and how matrix effects can be evaluated and avoided when analyzing such samples with LC-MS/MS. Moreover, a brief overview of sample preparation and the working mechanisms of LC-MS/MS and matrix effects is given.
ISSN: 1080-9945
Publication status: published
KU Leuven publication type: RE
Appears in Collections:Toxicology and Pharmacology
× corresponding author
# (joint) last author

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