Title: Protection of 2,6-diaminopurine 2'-deoxyriboside
Authors: Luyten, Ingrid
Van Aerschot, Arthur ×
Rozenski, Jef
Busson, Roger
Herdewijn, Piet #
Issue Date: 1997
Publisher: M. Dekker
Series Title: Nucleosides & Nucleotides vol:16 issue:7-9 pages:1649-1652
Abstract: Protection of both amine moieties of 2,6-diaminopurine 2'-deoxyriboside as a dimethylformamidine group did not proove feasable, while protection with a phenoxyacetyl group afforded only a mono-protected analogue 5. This analogue can be incorporated into oligonucleotides without difficulties. However, oligonucleotides with diaminopurine substituted for adenine did not yield more stable duplexes for the two sequences tested here.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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