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Title: Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a "watch and wait" strategy after complete resection
Authors: Attarbaschi, Andishe ×
Beishuizen, Auke
Mann, Georg
Rosolen, Angelo
Mori, Tetsuya
Uyttebroeck, Anne
Niggli, Felix
Csoka, Monika
Krenova, Zdenka
Mellgren, Karin
Kabickova, Edita
Chiang, Alan Ks
Reiter, Alfred
Williams, Denise
Burkhardt, Birgit
on behalf of the European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the international Berlin-Frankfurt-Münster (i-BFM) Study Group #
Issue Date: Nov-2013
Publisher: Springer International
Series Title: Annals of hematology vol:92 issue:11 pages:1537-41
Abstract: Data on clinical features and outcome in pediatric follicular lymphoma (pFL) are scarce. The aim of this retrospective study including 13 EICNHL and/or i-BFM study group members was to assess clinical characteristics and course in a series of 63 pFL patients. pFL was found to be associated with male gender (3:1), older age (72 % ≥10 years old), low serum LDH levels (<500 U/l in 75 %), grade 3 histology (in 88 %), and limited disease (87 % stage I/II disease), mostly involving the peripheral lymph nodes. Forty-four out of sixty-three patients received any polychemotherapy and 1/63 rituximab only, while 17/63 underwent a "watch and wait" strategy. Of 36 stage I patients, 30 had complete resections. Only one patient relapsed; 2-year event-free survival and overall survival were 94 ± 5 and 100 %, respectively, after a median follow-up of 2.2 years. Conclusively, treatment outcome in pFL seems to be excellent with risk-adapted chemotherapy or after complete resection and an observational strategy only.
ISSN: 0939-5555
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Organ Systems (+)
× corresponding author
# (joint) last author

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