Title: Hybridization properties of base-modified oligonucleotides within the double and triple helix motif
Authors: Luyten, Ingrid ×
Herdewijn, Piet #
Issue Date: Jul-1998
Publisher: Editions scientifiques medicales elsevier
Series Title: European journal of medicinal chemistry vol:33 issue:7-8 pages:515-576
Abstract: In this review we describe the influence of modified nucleobases in order to understand the changes they introduce in double and triple helix forming oligomers with the aim to study their potential therapeutic use in the antisense/antigene/ribozyme field. The hybridization properties of the studied modified oligomers depend on the structure of the modified nucleoside, the number of modifications, the selected sequence and the location of the modified nucleoside along the sequence. Unfortunately, most available information is based on melting point determination, eventually CD experiments and only in a few cases on X-ray and NMR studies which makes it difficult to put forward general rules for predicting modified nucleic acid structures. On the other hand, several of the described base modifications allow us to select new oligonucleotides with improved properties in the different application fields. (C) Elsevier, Paris.
ISSN: 0223-5234
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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