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Title: The electro-mechanical window in anaesthetized guinea pigs: a new marker in screening for Torsade de Pointes risk
Authors: Guns, P-J ×
Johnson, Daniel #
Van Op den Bosch, J
Weltens, E
Lissens, J #
Issue Date: May-2012
Publisher: Scientific & Medical Division, Macmillan Press
Series Title: British Journal of Pharmacology vol:166 issue:2 pages:689-701
Article number: 10.1111/j.1476-5381.2011.01795.x
Abstract: QT prolongation is commonly used as a surrogate marker for Torsade de Pointes (TdP) risk of non-cardiovascular drugs. However, use of this indirect marker often leads to misinterpretation of the realistic TdP risk, as tested compounds may cause QT prolongation without evoking TdP in humans. A negative electro-mechanical (E-M) window has recently been proposed as an alternative risk marker for TdP in a canine LQT1 model. Here, we evaluated the E-M window in anaesthetized guinea pigs as a screening marker for TdP in humans.
URI: 
ISSN: 0007-1188
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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