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Title: Drug-induced effects on cardiovascular function in pentobarbital anesthetized guinea-pigs: invasive LVP measurements versus the QA interval
Authors: Johnson, Daniel M # ×
Geys, R
Lissens, J
Guns, P J #
Issue Date: Sep-2012
Publisher: Elsevier
Series Title: Journal of Pharmacological and Toxicological Methods vol:66 issue:2 pages:152-9
Article number: 10.1016/j.vascn.2012.07.002
Abstract: Evaluation of drug-related effects on cardiovascular function is part of the core battery described in the ICH S7A guideline. Anesthetized guinea-pigs are excellent models for the evaluation of drug-induced prolongation of ventricular repolarization; however less information is available regarding other cardio-hemodynamic parameters in this model. The current study aimed to document cardio-hemodynamic responses in anesthetized guinea-pigs after administration of a number of reference drugs with known pharmacological actions.
URI: 
ISSN: 1056-8719
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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