Title: Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity
Authors: Wang, Jing ×
Verbeure, B
Luyten, Ingrid
Froeyen, Mathy
Hendrix, C
Rosemeyer, H
Seela, F
Van Aerschot, Arthur
Herdewijn, Piet #
Issue Date: 2001
Publisher: Marcel dekker inc
Series Title: Nucleosides, nucleotides & nucleic acids vol:20 issue:4-7 pages:785-788
Abstract: Cyclohexene nucleic acids (CeNA) were synthesized using classical phosporamidite chemistry. Incorporation of a cyclohexene nucleo-side in a DNA chain leads to an increase in stability of the DNA/RNA duplex. CeNA is stable against degradation in serum. A CeNA/RNA hybrid is able to activate E. Coli RNase H. resulting in cleavage of the RNA strand.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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