Reduced ventricular proarrhythmic potential of the novel combined ion-channel blocker AZD1305 versus dofetilide in dogs with remodeled hearts
Johnson, Daniel de Jong, Monique M J Crijns, Harry J G M Carlsson, Leif G Volders, Paul G A # ×
Lippincott Williams & Wilkins
Circulation. Arrhythmia and Electrophysiology vol:5 issue:1 pages:201-9
AZD1305 is an investigational antiarrhythmic agent for management of atrial fibrillation. It blocks various cardiac ion currents at different potencies and has atrial-predominant electrophysiological effects. We investigated the electrophysiological and proarrhythmic effects of AZD1305 versus dofetilide in dogs with chronic complete atrioventricular block and myocardial hypertrophic remodeling.