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Title: The remarkable conformational plasticity of alpha-synuclein: blessing or curse?
Authors: Deleersnijder, Angélique
Gérard, Melanie
Debyser, Zeger
Baekelandt, Veerle # ×
Issue Date: Jun-2013
Publisher: Elsevier Science Ltd.
Series Title: Trends in molecular medicine vol:19 issue:6 pages:368-377
Abstract: The aggregation of the protein alpha-synuclein (α-SYN) is believed to be a critical event in Parkinson's disease (PD). α-SYN is characterized by a remarkable conformational plasticity, adopting different conformations depending on the environment. In vitro, α-SYN lacks a well-defined structure. Therefore, it was classified as an 'intrinsically disordered protein'. A debate has recently begun over how α-SYN behaves in the cell: is it an intrinsically disordered protein or a stable tetramer with a low propensity for aggregation? In this review, we discuss the aggregation of α-SYN and describe factors that influence this process and their potential relevance in PD pathogenesis. We address the ways in which aggregated α-SYN mediates toxicity and might lead to PD, and propose possible therapeutic strategies.
ISSN: 1471-4914
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Virology and Gene Therapy
Research Group for Neurobiology and Gene Therapy
Pharmaceutical and Pharmacological Sciences @ Kulak (-)
× corresponding author
# (joint) last author

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