Title: Cyclization of tetra-L-alanine induced by complexation of technetium
Authors: Bormans, Guy ×
Peeters, OM
Vanbilloen, H
Blaton, Norbert
Verbruggen, Alfons #
Issue Date: Oct-1996
Publisher: Amer chemical soc
Series Title: Inorganic Chemistry vol:35 issue:21 pages:6240-6244
Abstract: Complexation of technetium with tetraalanine yields an unstable complex that converts to a monooxotechnetium(V) complex of cyclic tetraalanine. The structure of the latter was determined by single-crystal X-ray analysis. In this negatively charged complex, the technetium atom is coordinated to one oxygen and four amide nitrogen atoms. The more polar complex that is initially formed is assumed to be an oxotechnetium(V) complex of tetraalanine, with the oxotechnetium moiety coordinated to three amide nitrogen atoms and the amine nitrogen atom. In this complex, the carboxyl group would be forced in the vicinity of the free amine group, thereby facilitating amide formation and cyclization. Cyclization of tetra-L-alanine occurs on both no carrier added (technetium-99m) and carrier added (technetium-99) scale.
ISSN: 0020-1669
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmacy
× corresponding author
# (joint) last author

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