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Title: Study of the stability of erythromycin in neutral and alkaline-solutions by liquid-chromatography on poly(styrene-divinylbenzene)
Authors: Paesen, J ×
Khan, K
Roets, Eugene
Hoogmartens, Jos #
Issue Date: Jan-1994
Publisher: Elsevier science bv
Series Title: International journal of pharmaceutics vol:113 issue:2 pages:215-222
Abstract: A liquid chromatography method using poly(styrene-divinylbenzene) as the stationary phase was used as the analytical method to investigate the stability of the macrolide antibiotic erythromycin in neutral and alkaline solutions (pH 7.5-11). Decomposition of erythromycin A was monitored up to 20% of degradation. Three degradation products were detected: pseudoerythromycin A enol ether, pseudoerythromycin A hemiketal and a hydrolysis product of erythromycin A, i.e., the product with an opened lactone structure. The decomposition kinetics have been studied as a function of the ionic strength, the concentration of the buffer, the amount of methanol in the solvent and the temperature.
URI: 
ISSN: 0378-5173
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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