Title: Biomechanical factors and macrophages in plaque stability
Authors: Seneviratne, Anusha
Hulsmans, Maarten
Holvoet, Paul ×
Monaco, Claudia #
Issue Date: Jul-2013
Publisher: British Medical Association
Series Title: Cardiovascular research vol:99 issue:2 pages:284-93
Abstract: Thin-cap fibroatheromas (TCFAs) or vulnerable atherosclerotic plaques are considered a high-risk phenotype for acute cardiovascular events. TCFAs are identified by a thin rupture-prone fibrous cap, a large necrotic core, and a high content of leucocytes. Atherogenesis is dependent upon complex patterns of blood flow. Slow-flowing blood imposing low shear stress on the arterial wall up-regulates inflammatory signalling in endothelial cells and leucocytes, and modulates microRNAs to promote inflammation and monocyte recruitment. Hence, low shear stress is believed to promote conditions conducive to vulnerable plaque development. In this review, we explore how biomechanical factors modulate macrophage phenotype and plaque stability.
ISSN: 0008-6363
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Atherosclerosis and Metabolism (-)
× corresponding author
# (joint) last author

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