Title: Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation
Authors: Johnson, Daniel * #
Heijman, Jordi *
Bode, Elizabeth F
Greensmith, David J
van der Linde, Henk
Abi-Gerges, Najah
Eisner, David A
Trafford, Andrew W
Volders, Paul G A # ×
Issue Date: Jan-2013
Publisher: Lippincott Williams & Wilkins
Series Title: Circulation Research vol:112 issue:2 pages:246-56
Article number: 10.1161/CIRCRESAHA.112.275735
Abstract: Spontaneous Ca(2+) release (SCR) from the sarcoplasmic reticulum can cause delayed afterdepolarizations and triggered activity, contributing to arrhythmogenesis during β-adrenergic stimulation. Excessive beat-to-beat variability of repolarization duration (BVR) is a proarrhythmic marker. Previous research has shown that BVR is increased during intense β-adrenergic stimulation, leading to SCR.
ISSN: 0009-7330
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
* (joint) first author
× corresponding author
# (joint) last author

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