Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation
Johnson, Daniel * # Heijman, Jordi * Bode, Elizabeth F Greensmith, David J van der Linde, Henk Abi-Gerges, Najah Eisner, David A Trafford, Andrew W Volders, Paul G A # ×
Lippincott Williams & Wilkins
Circulation Research vol:112 issue:2 pages:246-56
Spontaneous Ca(2+) release (SCR) from the sarcoplasmic reticulum can cause delayed afterdepolarizations and triggered activity, contributing to arrhythmogenesis during β-adrenergic stimulation. Excessive beat-to-beat variability of repolarization duration (BVR) is a proarrhythmic marker. Previous research has shown that BVR is increased during intense β-adrenergic stimulation, leading to SCR.