ITEM METADATA RECORD
Title: Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219
Authors: Frey, Christian R ×
Andrei, Graciela
Votruba, Ivan
Cannizzaro, Carina
Han, Bin
Fung, Wanchi
Hung, Magdeleine
Liu, Xiaohong
Geleziunas, Romas
Fiten, Pierre
Opdenakker, Ghislain
Snoeck, Robert
Cihlar, Tomas #
Issue Date: May-2013
Publisher: Potamitis Press
Series Title: Anticancer Research vol:33 issue:5 pages:1899-1912
Abstract: Background/Aim: GS 9219 is a double prodrug of antiproliferative nucleotide analog 9-(2-Phosphonylmethoxyethyl)guanine (PMEG), with potent in vivo efficacy against various hematological malignancies. This study investigates the role of adenosine deaminase-like (ADAL) protein in the intracellular activation of GS-9219.
URI: 
ISSN: 0250-7005
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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