Immunoglobulin deficiencies: the B-lymphocyte side of DiGeorge Syndrome
Patel, Kiran × Akhter, Javeed Kobrynski, Lisa Benjamin Gathmann, M A Gathman, Benjamin Davis, Onika Sullivan, Kathleen E Meyts, Isabelle #
Journal of Pediatrics vol:161 issue:5 pages:950-3
DiGeorge syndrome is associated with a T-lymphocyte immunodeficiency. The prevalence of hypogammaglobulinemia has not been reported. We found that 3% of patients with DiGeorge syndrome were receiving immunoglobulin replacement therapy and 6% of patients over the age of 3 years had hypogammaglobulinemia. We conclude that DiGeorge syndrome is associated with significant humoral immune deficiency.