Title: Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging
Authors: Agius, Elaine ×
Lacy, Katie E
Vukmanovic-Stejic, Milica
Jagger, Ann L
Papageorgiou, Anna-Pia
Hall, Sue
Reed, John R
Curnow, S John
Fuentes-Duculan, Judilyn
Buckley, Christopher D
Salmon, Mike
Taams, Leonie S
Krueger, James
Greenwood, John
Klein, Nigel
Rustin, Malcolm H A
Akbar, Arne N #
Issue Date: Aug-2009
Publisher: Rockefeller Institute for Medical Research
Series Title: Journal of Experimental Medicine vol:206 issue:9 pages:1929-40
Article number: 10.1084/jem.20090896
Abstract: Immunity declines during aging, however the mechanisms involved in this decline are not known. In this study, we show that cutaneous delayed type hypersensitivity (DTH) responses to recall antigens are significantly decreased in older individuals. However, this is not related to CC chemokine receptor 4, cutaneous lymphocyte-associated antigen, or CD11a expression by CD4(+) T cells or their physical capacity for migration. Instead, there is defective activation of dermal blood vessels in older subject that results from decreased TNF-alpha secretion by macrophages. This prevents memory T cell entry into the skin after antigen challenge. However, isolated cutaneous macrophages from these subjects can be induced to secrete TNF-alpha after stimulation with Toll-like receptor (TLR) 1/2 or TLR 4 ligands in vitro, indicating that the defect is reversible. The decreased conditioning of tissue microenvironments by macrophage-derived cytokines may therefore lead to defective immunosurveillance by memory T cells. This may be a predisposing factor for the development of malignancy and infection in the skin during aging.
ISSN: 0022-1007
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
× corresponding author
# (joint) last author

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