Title: Improving outcomes in the first-line management of advanced ovarian cancer
Authors: Vergote, Ignace ×
Van Gorp, Toon
Cadron, Isabelle
Leunen, Karin
Neven, Patrick
Amant, Frédéric #
Issue Date: Jan-2007
Publisher: Pergamon/Elsevier
Series Title: European Journal of Cancer Supplements vol:5 issue:1 pages:23-28
Abstract: Carboplatin plus paclitaxel is the standard first-line chemotherapy for ovarian carcinoma. Primary debulking surgery is likely to remain the standard of care for advanced disease until results from the EORTC trial on neoadjuvant chemotherapy are available. A number of methods of improving chemotherapy treatment have been investigated. However, few trials have been conducted and insufficient data collected to date to support intraperitoneal (IP) delivery as standard first-line chemotherapy, in part due to concerns over potential toxicity. There is an unmet need for an appropriate IP trial (preferentially with carboplatin) for comparison with intravenous carboplatin and paclitaxel. Triplet or sequential doublet combinations have similarly not yet shown any advantage over standard doublet therapy. There is also insufficient evidence to date that maintenance therapy following standard chemotherapy improves overall survival. However, it is hoped that current trials examining tyrosine kinase inhibitors, vascular endothelial growth factor inhibitors and other multi-targeted biological agents will yield promising options for concomitant use with first-line chemotherapy or as maintenance therapy.
ISSN: 1359-6349
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Woman - Miscellaneous (-)
Gynaecological Oncology
× corresponding author
# (joint) last author

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