Title: Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats
Authors: Herdewyn, Sarah ×
De Muynck, Louis
Van Den Bosch, Ludo
Robberecht, Wim
Van Damme, Philip #
Issue Date: Oct-2013
Publisher: Elsevier
Series Title: Neurobiology of aging vol:34 issue:10 pages:2302-3
Article number: S0197-4580(13)00146-2
Abstract: Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is familial in 10% of patients, with mutations in SOD1 and C9orf72 being the most frequent cause. There is convincing evidence for overlap between ALS and frontotemporal lobar degeneration at the genetic, pathological, and clinical level. Null mutations in progranulin (PGRN) are a frequent cause of familial frontotemporal lobar degeneration. PGRN exerts neurotrophic properties on motor neurons in vitro and in vivo. We therefore examined whether PGRN could affect disease progression in mutant SOD1 mice and rats, both established models for ALS. Overexpression of PGRN in mice and intracerebroventricular delivery of PGRN in rats did not affect onset or progression of motor neuron degeneration.
ISSN: 0197-4580
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Neurobiology
× corresponding author
# (joint) last author

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