L-dopa gains psychostimulant-like properties after nigral dopaminergic loss
Engeln, Michel Fasano, Stefania Ahmed, Serge H Cador, Martine Baekelandt, Veerle Bezard, Erwan Fernagut, Pierre-Olivier # ×
American Neurological Association
Annals of Neurology vol:74 issue:1 pages:140-144
Dopamine Dysregulation Syndrome shares some core behavioral features of psychostimulant addiction, suggesting that dopamine replacement therapy can acquire psychostimulant-like properties in some patients with Parkinson's disease (PD). We here report strong experimental evidence supporting this hypothesis in an alpha-synuclein rat model of PD. Though L-Dopa had no effect in controls, it acquired two prominent psychostimulant-like properties in Parkinsonian rats: i) it produced intense reward on its own and in parallel ii) decreased interest in other nondrug reward. These two effects may combine to explain the addictive use of L-Dopa after loss of midbrain dopamine neurons in some PD patients. ANN NEUROL 2010.