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Title: L-dopa gains psychostimulant-like properties after nigral dopaminergic loss
Authors: Engeln, Michel
Fasano, Stefania
Ahmed, Serge H
Cador, Martine
Baekelandt, Veerle
Bezard, Erwan
Fernagut, Pierre-Olivier # ×
Issue Date: Mar-2013
Publisher: American Neurological Association
Series Title: Annals of Neurology vol:74 issue:1 pages:140-144
Article number: 10.1002/ana.23881
Abstract: Dopamine Dysregulation Syndrome shares some core behavioral features of psychostimulant addiction, suggesting that dopamine replacement therapy can acquire psychostimulant-like properties in some patients with Parkinson's disease (PD). We here report strong experimental evidence supporting this hypothesis in an alpha-synuclein rat model of PD. Though L-Dopa had no effect in controls, it acquired two prominent psychostimulant-like properties in Parkinsonian rats: i) it produced intense reward on its own and in parallel ii) decreased interest in other nondrug reward. These two effects may combine to explain the addictive use of L-Dopa after loss of midbrain dopamine neurons in some PD patients. ANN NEUROL 2010.
URI: 
ISSN: 0364-5134
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group for Neurobiology and Gene Therapy
× corresponding author
# (joint) last author

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