Title: Application of the thermodynamics of mobile order and disorder to explain the solubility of temazepam in aqueous solutions of polyethylene glycol 6000
Authors: Van den Mooter, Guy ×
Augustijns, Patrick
Kinget, Renaat #
Issue Date: 13-Apr-1998
Series Title: International journal of pharmaceutics vol:164 issue:1-2 pages:81-89
Abstract: The aqueous solubility of temazepam, a poorly water-soluble drug, markedly increased when polyethylene glycol (PEG) 6000 was added to the solvent. To a first approximation this enhancement is proportional to the weight fraction of the polymer, and al a concentration of 15% w/w of PEG 6000, the solubility increased by a factor of two at 24 degrees C. Similar observations were made at 34 and 46 degrees C. The linearity of the solubility effect was investigated using the new thermodynamics of the mobile order and disorder. It is hypothesized that random mixing is unlikely to occur, but instead, a segregation of the binary solvent in zones with a high or low polymer concentration is suggested.
ISSN: 0378-5173
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
× corresponding author
# (joint) last author

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