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Title: Plasminogen Controls Inflammation and Pathogenesis of Influenza Virus Infections via Fibrinolysis
Authors: Berri, Fatma ×
Rimmelzwaan, Guus F
Hanss, Michel
Albina, Emmanuel
Foucault-Grunenwald, Marie-Laure
Lê, Vuong B
Vogelzang-van Trierum, Stella E
Gil, Patrica
Camerer, Eric
Martinez, Dominique
Lina, Bruno
Lijnen, Roger
Carmeliet, Peter
Riteau, Béatrice #
Issue Date: Mar-2013
Publisher: Public Library of Science
Series Title: PLoS Pathogens vol:9 issue:3 pages:e1003229
Article number: 10.1371/journal.ppat.1003229
Abstract: Detrimental inflammation of the lungs is a hallmark of severe influenza virus infections. Endothelial cells are the source of cytokine amplification, although mechanisms underlying this process are unknown. Here, using combined pharmacological and gene-deletion approaches, we show that plasminogen controls lung inflammation and pathogenesis of infections with influenza A/PR/8/34, highly pathogenic H5N1 and 2009 pandemic H1N1 viruses. Reduction of virus replication was not responsible for the observed effect. However, pharmacological depletion of fibrinogen, the main target of plasminogen reversed disease resistance of plasminogen-deficient mice or mice treated with an inhibitor of plasminogen-mediated fibrinolysis. Therefore, plasminogen contributes to the deleterious inflammation of the lungs and local fibrin clot formation may be implicated in host defense against influenza virus infections. Our studies suggest that the hemostatic system might be explored for novel treatments against influenza.
URI: 
ISSN: 1553-7366
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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