Title: Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting
Authors: Langlet, Fanny ×
Levin, Barry E
Luquet, Serge
Mazzone, Max
Messina, Andrea
Dunn-Meynell, Ambrose A
Balland, Eglantine
Lacombe, Amelie
Mazur, Daniele
Carmeliet, Peter
Bouret, Sebastien G
Prevot, Vincent
Dehouck, Bénédicte #
Issue Date: Apr-2013
Publisher: Cell Press
Series Title: Cell Metabolism vol:17 issue:4 pages:607-617
Article number: 10.1016/j.cmet.2013.03.004
Abstract: The delivery of blood-borne molecules conveying metabolic information to neural networks that regulate energy homeostasis is restricted by brain barriers. The fenestrated endothelium of median eminence microvessels and tight junctions between tanycytes together compose one of these. Here, we show that the decrease in blood glucose levels during fasting alters the structural organization of this blood-hypothalamus barrier, resulting in the improved access of metabolic substrates to the arcuate nucleus. These changes are mimicked by 2-deoxyglucose-induced glucoprivation and reversed by raising blood glucose levels after fasting. Furthermore, we show that VEGF-A expression in tanycytes modulates these barrier properties. The neutralization of VEGF signaling blocks fasting-induced barrier remodeling and significantly impairs the physiological response to refeeding. These results implicate glucose in the control of blood-hypothalamus exchanges through a VEGF-dependent mechanism and demonstrate a hitherto unappreciated role for tanycytes and the permeable microvessels associated with them in the adaptive metabolic response to fasting.
ISSN: 1550-4131
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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