Title: Prospective Comparison of Hydrogel-coated Microcoils Versus Fibered Platinum Microcoils in the Prophylactic Embolization of the Gastroduodenal Artery before Yttrium-90 Radioembolization
Authors: Maleux, Geert ×
Deroose, Christophe
Fieuws, Steffen
Van Cutsem, Eric
Heye, Sam
Bosmans, Hilde
Verslype, Chris #
Issue Date: Jun-2013
Publisher: Society of Cardiovascular & Interventional Radiology
Series Title: Journal of Vascular and Interventional Radiology vol:24 issue:6 pages:797-803
Article number: S1051-0443(13)00604-0
Abstract: PURPOSE: To prospectively assess the performance of hydrogel-coated versus fibered microcoils in the prophylactic occlusion of the gastroduodenal artery (GDA) before yttrium-90 ((90)Y) radioembolization. MATERIALS AND METHODS: A total of 43 patients were randomized to receive fibered microcoils (n = 15), detachable hydrogel-coated microcoils (n = 13), or pushable hydrogel-coated microcoils (n = 15). Numbers of coils used, duration, dose-area product (DAP), contrast agent load, and coil migration were assessed. At the time of yttrium-90 ((90)Y) radioembolization, persistent GDA occlusion was analyzed. RESULTS: In all patients, the embolized GDA was still completely occluded at the time of (90)Y radioembolization. Mean numbers of microcoils used per patient were 11.5 (fibered microcoils), 2.9 (detachable hydrocoils), and 5.5 (pushable hydrocoils), with all numbers significantly different (P<.0001). Mean DAPs were 16,283 mGy/cm(2)±16,545 (standard deviation) for fibered microcoils, 13,786 mGy/cm(2)±5,990 for detachable hydrocoils, and 35,757 mGy/cm(2)±74,493 for pushable hydrocoils (P = .87). Mean durations of GDA coil embolization were 20 minutes for fibered microcoils, 25 minutes for detachable hydrocoils, and 32 minutes for pushable hydrocoils (P = .0015). Mean contrast agent loads were 9 mL for fibered microcoils, 11 mL for pushable hydrocoils, and 7 mL for detachable hydrocoils (P = .13). One case of coil migration occurred with each type. CONCLUSIONS: Hydrogel-coated and fibered microcoils are equally effective for prophylactic occlusion of the GDA before radioembolization. The number of coils used is higher with fibered microcoils compared with pushable and detachable hydrocoils, but the reduced number of hydrocoils comes at the cost of increased procedure duration.
ISSN: 1051-0443
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat)
× corresponding author
# (joint) last author

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