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Title: The prognostic role of preoperative and (early) postoperatively change in CA15.3 serum levels in a single hospital cohort of primary operable breast cancers
Authors: Brouckaert, O ×
Laenen, Annouschka
Wildiers, Hans
Floris, Guiseppe
Moerman, Philippe
Van Limbergen, Erik
Vergote, Ignace
Billen, Jaak
Christiaens, Rose
Neven, Patrick #
Issue Date: Jun-2013
Publisher: Churchill Livingstone
Series Title: The Breast vol:22 issue:3 pages:254-62
Article number: S0960-9776(13)00054-4
Abstract: Measuring CA15.3 serum levels in the early breast cancer setting is not recommended by current ASCO guidelines. In this large single center study, we assess the prognostic value of preoperative (n = 3746), postoperative (n = 4049) and change in (n = 3252) CA15.3, also across different breast cancer phenotypes. Preoperative, postoperative and change in CA15.3 were all significant (p = 0.0348, p < 0.0001, p < 0.0001 respectively in multivariate analysis) predictors of distant metastasis free survival. For breast cancer specific survival, only postoperative and change in CA15.3 were significant predictors (p < 0.0001 both). Multivariate prognostic models did not improve by incorporating information on preoperative CA15.3, but did improve when introducing information on postoperative CA15.3 for distant metastasis (p = 0.0365) and on change in CA15.3 for breast cancer specific survival (p = 0.0291). Change in CA15.3 impacts on prognosis (distant metastasis) differently in different breast cancer phenotypes. A decrease in CA15.3 may be informative of improved prognosis in basal like and HER2 like breast cancer.
URI: 
ISSN: 0960-9776
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
Translational Cell & Tissue Research
Laboratory of Experimental Radiotherapy
Clinical and Experimental Endocrinology
Surgical Oncology
Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat)
× corresponding author
# (joint) last author

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