ITEM METADATA RECORD
Title: Genome-wide association studies identify four ER negative-specific breast cancer risk loci
Authors: Garcia-Closas, Montserrat ×
Couch, Fergus J
Lindstrom, Sara
Michailidou, Kyriaki
Schmidt, Marjanka K
Brook, Mark N
Orr, Nick
Rhie, Suhn Kyong
Riboli, Elio
Feigelson, Heather S
Le Marchand, Loic
Buring, Julie E
Eccles, Diana
Miron, Penelope
Fasching, Peter A
Brauch, Hiltrud
Chang-Claude, Jenny
Carpenter, Jane
Godwin, Andrew K
Nevanlinna, Heli
Giles, Graham G
Cox, Angela
Hopper, John L
Bolla, Manjeet K
Wang, Qin
Dennis, Joe
Dicks, Ed
Howat, Will J
Schoof, Nils
Bojesen, Stig E
Lambrechts, Diether
Broeks, Annegien
Andrulis, Irene L
Guénel, Pascal
Burwinkel, Barbara
Sawyer, Elinor J
Hollestelle, Antoinette
Fletcher, Olivia
Winqvist, Robert
Brenner, Hermann
Mannermaa, Arto
Hamann, Ute
Meindl, Alfons
Lindblom, Annika
Zheng, Wei
Devillee, Peter
Goldberg, Mark S
Lubinski, Jan
Kristensen, Vessela
Swerdlow, Anthony
Anton-Culver, Hoda
Dörk, Thilo
Muir, Kenneth
Matsuo, Keitaro
Wu, Anna H
Radice, Paolo
Teo, Soo Hwang
Shu, Xiao-Ou
Blot, William
Kang, Daehee
Hartman, Mikael
Sangrajrang, Suleeporn
Shen, Chen-Yang
Southey, Melissa C
Park, Daniel J
Hammet, Fleur
Stone, Jennifer
Veer, Laura J Van't
Rutgers, Emiel J
Lophatananon, Artitaya
Stewart-Brown, Sarah
Siriwanarangsan, Pornthep
Peto, Julian
Schrauder, Michael G
Ekici, Arif B
Beckmann, Matthias W
Dos Santos Silva, Isabel
Johnson, Nichola
Warren, Helen
Tomlinson, Ian
Kerin, Michael J
Miller, Nicola
Marme, Federick
Schneeweiss, Andreas
Sohn, Christof
Truong, Therese
Laurent-Puig, Pierre
Kerbrat, Pierre
Nordestgaard, Børge G
Nielsen, Sune F
Flyger, Henrik
Milne, Roger L
Perez, Jose Ignacio Arias
Menéndez, Primitiva
Müller, Heiko
Arndt, Volker
Stegmaier, Christa
Lichtner, Peter
Lochmann, Magdalena
Justenhoven, Christina
Ko, Yon-Dschun
Gene ENvironmental Interaction and breast CAncer (GENICA) Network
Muranen, Taru A
Aittomäki, Kristiina
Blomqvist, Carl
Greco, Dario
Heikkinen, Tuomas
Ito, Hidemi
Iwata, Hiroji
Yatabe, Yasushi
Antonenkova, Natalia N
Margolin, Sara
Kataja, Vesa
Kosma, Veli-Matti
Hartikainen, Jaana M
Balleine, Rosemary
kConFab Investigators
Tseng, Chiu-Chen
Berg, David Van Den
Stram, Daniel O
Neven, Patrick
Dieudonné, Anne-Sophie
Leunen, Karin
Rudolph, Anja
Nickels, Stefan
Flesch-Janys, Dieter
Peterlongo, Paolo
Peissel, Bernard
Bernard, Loris
Olson, Janet E
Wang, Xianshu
Stevens, Kristen
Severi, Gianluca
Baglietto, Laura
McLean, Catriona
Coetzee, Gerhard A
Feng, Ye
Henderson, Brian E
Schumacher, Fredrick
Bogdanova, Natalia V
Labrèche, France
Dumont, Martine
Yip, Cheng Har
Taib, Nur Aishah Mohd
Cheng, Ching-Yu
Shrubsole, Martha
Long, Jirong
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Kauppila, Saila
Knight, Julia A
Glendon, Gord
Mulligan, Anna Marie
Tollenaar, Robertus A E M
Seynaeve, Caroline M
Kriege, Mieke
Hooning, Maartje J
van den Ouweland, Ans M W
van Deurzen, Carolien H M
Lu, Wei
Gao, Yu-Tang
Cai, Hui
Balasubramanian, Sabapathy P
Cross, Simon S
Reed, Malcolm W R
Signorello, Lisa
Cai, Qiuyin
Shah, Mitul
Miao, Hui
Chan, Ching Wan
Chia, Kee Seng
Jakubowska, Anna
Jaworska, Katarzyna
Durda, Katarzyna
Hsiung, Chia-Ni
Wu, Pei-Ei
Yu, Jyh-Cherng
Ashworth, Alan
Jones, Michael
Tessier, Daniel C
González-Neira, Anna
Pita, Guillermo
Alonso, M Rosario
Vincent, Daniel
Bacot, Francois
Ambrosone, Christine B
Bandera, Elisa V
John, Esther M
Chen, Gary K
Hu, Jennifer J
Rodriguez-Gil, Jorge L
Bernstein, Leslie
Press, Michael F
Ziegler, Regina G
Millikan, Robert M
Deming-Halverson, Sandra L
Nyante, Sarah
Ingles, Sue A
Waisfisz, Quinten
Tsimiklis, Helen
Makalic, Enes
Schmidt, Daniel
Bui, Minh
Gibson, Lorna
Müller-Myhsok, Bertram
Schmutzler, Rita K
Hein, Rebecca
Dahmen, Norbert
Beckmann, Lars
Aaltonen, Kirsimari
Czene, Kamila
Irwanto, Astrid
Liu, Jianjun
Turnbull, Clare
Familial Breast Cancer Study (FBCS)
Rahman, Nazneen
Meijers-Heijboer, Hanne
Uitterlinden, Andre G
Rivadeneira, Fernando
stralian Breast Cancer Tissue Bank (ABCTB) Investigators
Olswold, Curtis
Slager, Susan
Pilarski, Robert
Ademuyiwa, Foluso
Konstantopoulou, Irene
Martin, Nicholas G
Montgomery, Grant W
Slamon, Dennis J
Rauh, Claudia
Lux, Michael P
Jud, Sebastian M
Bruning, Thomas
Weaver, Joellen
Sharma, Priyanka
Pathak, Harsh
Tapper, Will
Gerty, Sue
Durcan, Lorraine
Trichopoulos, Dimitrios
Tumino, Rosario
Peeters, Petra H
Kaaks, Rudolf
Campa, Daniele
Canzian, Federico
Weiderpass, Elisabete
Johansson, Mattias
Khaw, Kay-Tee
Travis, Ruth
Clavel-Chapelon, Françoise
Kolonel, Laurence N
Chen, Constance
Beck, Andy
Hankinson, Susan E
Berg, Christine D
Hoover, Robert N
Lissowska, Jolanta
Figueroa, Jonine D
Chasman, Daniel I
Gaudet, Mia M
Diver, W Ryan
Willett, Walter C
Hunter, David J
Simard, Jacques
Benitez, Javier
Dunning, Alison M
Sherman, Mark E
Chenevix-Trench, Georgia
Chanock, Stephen J
Hall, Per
Pharoah, Paul D P
Vachon, Celine
Easton, Douglas F
Haiman, Christopher A
Kraft, Peter #
Issue Date: Apr-2013
Publisher: Nature Publishing Group
Series Title: Nature Genetics vol:45 issue:4 pages:392-8
Article number: 10.1038/ng.2561
Abstract: Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10(-12) and LGR6, P = 1.4 × 10(-8)), 2p24.1 (P = 4.6 × 10(-8)) and 16q12.2 (FTO, P = 4.0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.
URI: 
ISSN: 1061-4036
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Translational Genetics (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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