Title: Proof of concept for the inhibition of foot-and-mouth disease virus replication by the anti-viral drug 2'-C-methylcytidine in severe combined immunodeficient mice
Authors: Lefebvre, D J ×
De Vleeschauwer, A R
Goris, N
Kollanur, D
Billiet, A
Murao, L
Neyts, Johan
De Clercq, K #
Issue Date: Dec-2014
Publisher: Wiley-Blackwell Publishing, Inc
Series Title: Transboundary and Emerging Diseases vol:61 issue:6 pages:e89-91
Article number: 10.1111/tbed.12069
Abstract: Recent European contingency plans envisage emergency vaccination as an animal-friendly control strategy for foot-and-mouth disease (FMD). Anti-viral drugs may be used as an alternative or complementary measure. We here demonstrate that the nucleoside analogue 2'-C-methylcytidine (2'CMC) protects severe combined immunodeficient (SCID) mice against lethal FMD virus infection. In brief, SCID mice were inoculated with serotype A FMD virus and treated for five consecutive days with 2'CMC. All 15 treated mice remained healthy until the end of the study at 14 days post-infection (dpi). At that time, viral RNA was no longer detected in 13 of 15 treated mice. All eight untreated mice suffered from an acute generalized disease and were euthanized for ethical reasons on average at 4 dpi. These results illustrate the potential of small molecules to control FMD.
ISSN: 1865-1674
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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