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Title: Synthesis and biological evaluation of novel 1,2,3-triazolonucleotides
Authors: Głowacka, Iwona E ×
Balzarini, Jan
Wróblewski, Andrzej E #
Issue Date: Apr-2013
Publisher: VCH Verlagsgesellschaft mbH
Series Title: Archiv der Pharmazie vol:346 issue:4 pages:278-91
Article number: 10.1002/ardp.201200421
Abstract: A general procedure for the preparation of 1,2,3-triazole analogs of nucleosides from diethyl 2-azidoethoxymethyl- and 2-azidoethoxyethylphosphonates was elaborated. The application of microwave irradiation shortened the reaction time to 10 min in comparison to ca. 48 h when 1,3-dipolar cycloadditions were performed under standard conditions. All compounds were evaluated in vitro for inhibitory activity against a broad variety of DNA and RNA viruses. None of the compounds were antivirally active at subtoxic concentrations. Compound 17k exhibited moderate inhibitory effects on the proliferation of human T-lymphocyte cells (IC50  = 64 µM for CEM).
URI: 
ISSN: 0365-6233
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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