Title: Role of semaphorins in the adult nervous system
Authors: de Wit, Joris ×
Verhaagen, J #
Issue Date: Oct-2003
Publisher: Pergamon Press
Series Title: Progress in Neurobiology vol:71 issue:2-3 pages:249-267
Abstract: Abstract
In the developing nervous system, extending axons are directed towards their appropriate targets by a myriad of attractive and repulsive
guidance cues. Work in the past decade has significantly advanced our understanding of these molecules and has made it increasingly clear
that their function is not limited to the guidance of growing axons during embryogenesis. Axon guidance cues fulfill additional roles in
angiogenesis, cell migration and the immune system, and often display sustained expression in adulthood. Here we focus on the semaphorin
(Sema) family and review their proposed functions in the adult nervous system. Several semaphorin family members continue to be expressed
in the adult brain and spinal cord, and increasing evidence indicates that their expression is regulated upon nervous system injury in rodents and
in neuropathology in humans. The available evidence suggests that semaphorins might significantly contribute to the maintenance and stability
of neuronal networks. Furthermore, semaphorins could play important roles in the regeneration, or failure thereof, of neuronal connections. In
the future, genetic manipulation of semaphorins and their receptors in the adult intact and injured nervous system should provide a deeper
insight into the mechanisms by which semaphorin signaling contributes to structural plasticity and regeneration in the adult brain.
ISSN: 0301-0082
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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