Title: Molecular Mechanisms of Synaptic Specificity in Developing Neural Circuits
Authors: Williams, Megan E
de Wit, Joris
Ghosh, Anirvan # ×
Issue Date: Oct-2010
Publisher: Cell Press
Series Title: Neuron vol:68 issue:1 pages:9-18
Abstract: Abstract
The function of the brain depends on highly specific patterns of connections between populations
of neurons. The establishment of these connections requires the targeting of axons and dendrites to
defined zones or laminae, the recognition of individual target cells, the formation of synapses on
particular regions of the dendritic tree, and the differentiation of pre- and postsynaptic
specializations. Recent studies provide compelling evidence that transmembrane adhesion proteins
of the immunoglobulin, cadherin, and leucine-rich repeat protein families, as well as secreted
proteins such as semaphorins and FGFs, regulate distinct aspects of neuronal connectivity. These
observations suggest that the coordinated actions of a number of molecular signals contribute to
the specification and differentiation of synaptic connections in the developing brain.
ISSN: 0896-6273
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Williams- Neuron 2010.pdfmain article Published 564KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science