Title: NGL-2 Regulates Input-Specific Synapse Development in CA1 Pyramidal Neurons
Authors: DeNardo, Laura A
de Wit, Joris
Otto-Hitt, Stefanie
Ghosh, Anirvan # ×
Issue Date: Nov-2012
Publisher: Cell Press
Series Title: Neuron vol:76 issue:4 pages:762-775
Abstract: SUMMARY
An important organizing feature of the CNS is that
individual neurons receive input from many different
sources. Independent regulation of synaptic input is
critical for the function and adaptive responses of
the nervous system, but the underlying molecular
mechanisms are not well understood. We identify
the leucine-rich repeat (LRR)-containing protein
NGL-2 (Lrrc4) as a key regulator of input-specific
synapse development in the hippocampus. Using
genetic deletion and shRNA-mediated knockdown,
we demonstrate a role for NGL-2 in regulating the
strength of synaptic transmission and spine density
specifically at Schaffer collateral synapses in the
stratum radiatum (SR) in CA1. NGL-2 protein is
restricted to SR and spine regulation requires NGL-
2’s LRR and PDZ-binding domains. Finally, loss of
NGL-2 disrupts cooperative interactions between
distal and proximal synapses in CA1 pyramidal cells.
These results demonstrate that NGL-2 is critical for
pathway-specific synapse development and functional
integration of distinct inputs.
ISSN: 0896-6273
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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