ITEM METADATA RECORD
Title: GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer
Authors: Pharoah, Paul D P ×
Tsai, Ya-Yu
Ramus, Susan J
Phelan, Catherine M
Goode, Ellen L
Lawrenson, Kate
Buckley, Melissa
Fridley, Brooke L
Tyrer, Jonathan P
Shen, Howard
Weber, Rachel
Karevan, Rod
Larson, Melissa C
Song, Honglin
Tessier, Daniel C
Bacot, François
Vincent, Daniel
Cunningham, Julie M
Dennis, Joe
Dicks, Ed
stralian Cancer Study
stralian Ovarian Cancer Study Group
Aben, Katja K
Anton-Culver, Hoda
Antonenkova, Natalia
Armasu, Sebastian M
Baglietto, Laura
Bandera, Elisa V
Beckmann, Matthias W
Birrer, Michael J
Bloom, Greg
Bogdanova, Natalia
Brenton, James D
Brinton, Louise A
Brooks-Wilson, Angela
Brown, Robert
Butzow, Ralf
Campbell, Ian
Carney, Michael E
Carvalho, Renato S
Chang-Claude, Jenny
Chen, Y Anne
Chen, Zhihua
Chow, Wong-Ho
Cicek, Mine S
Coetzee, Gerhard
Cook, Linda S
Cramer, Daniel W
Cybulski, Cezary
Dansonka-Mieszkowska, Agnieszka
Despierre, Evelyn
Doherty, Jennifer A
Dörk, Thilo
du Bois, Andreas
Dürst, Matthias
Eccles, Diana
Edwards, Robert
Ekici, Arif B
Fasching, Peter A
Fenstermacher, David
Flanagan, James
Gao, Yu-Tang
Garcia-Closas, Montserrat
Gentry-Maharaj, Aleksandra
Giles, Graham
Gjyshi, Anxhela
Gore, Martin
Gronwald, Jacek
Guo, Qi
Halle, Mari K
Harter, Philipp
Hein, Alexander
Heitz, Florian
Hillemanns, Peter
Hoatlin, Maureen
Høgdall, Estrid
Høgdall, Claus K
Hosono, Satoyo
Jakubowska, Anna
Jensen, Allan
Kalli, Kimberly R
Karlan, Beth Y
Kelemen, Linda E
Kiemeney, Lambertus A
Kjaer, Susanne Krüger
Konecny, Gottfried E
Krakstad, Camilla
Kupryjanczyk, Jolanta
Lambrechts, Diether
Lambrechts, Sandrina
Le, Nhu D
Lee, Nathan
Lee, Janet
Leminen, Arto
Lim, Boon Kiong
Lissowska, Jolanta
Lubiński, Jan
Lundvall, Lene
Lurie, Galina
Massuger, Leon F A G
Matsuo, Keitaro
McGuire, Valerie
McLaughlin, John R
Menon, Usha
Modugno, Francesmary
Moysich, Kirsten B
Nakanishi, Toru
Narod, Steven A
Ness, Roberta B
Nevanlinna, Heli
Nickels, Stefan
Noushmehr, Houtan
Odunsi, Kunle
Olson, Sara
Orlow, Irene
Pejovic, Tanja
Pelttari, Liisa M
Permuth-Wey, Jenny
Pike, Malcolm C
Poole, Elizabeth M
Qu, Xiaotao
Risch, Harvey A
Rodriguez-Rodriguez, Lorna
Rossing, Mary Anne
Rudolph, Anja
Runnebaum, Ingo
Rzepecka, Iwona K
Salvesen, Helga B
Schwaab, Ira
Severi, Gianluca
Shen, Hui
Shridhar, Vijayalakshmi
Shu, Xiao-Ou
Sieh, Weiva
Southey, Melissa C
Spellman, Paul
Tajima, Kazuo
Teo, Soo-Hwang
Terry, Kathryn L
Thompson, Pamela J
Timorek, Agnieszka
Tworoger, Shelley S
van Altena, Anne M
van den Berg, David
Vergote, Ignace
Vierkant, Robert A
Vitonis, Allison F
Wang-Gohrke, Shan
Wentzensen, Nicolas
Whittemore, Alice S
Wik, Elisabeth
Winterhoff, Boris
Woo, Yin Ling
Wu, Anna H
Yang, Hannah P
Zheng, Wei
Ziogas, Argyrios
Zulkifli, Famida
Goodman, Marc T
Hall, Per
Easton, Douglas F
Pearce, Celeste L
Berchuck, Andrew
Chenevix-Trench, Georgia
Iversen, Edwin
Monteiro, Alvaro N A
Gayther, Simon A
Schildkraut, Joellen M
Sellers, Thomas A #
Issue Date: Apr-2013
Publisher: Nature Publishing Group
Series Title: Nature Genetics vol:45 issue:4 pages:362-70
Article number: 10.1038/ng.2564
Abstract: Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the UK. We selected the top 24,551 SNPs for inclusion on the iCOGS custom genotyping array. We performed follow-up genotyping in 18,174 individuals with EOC (cases) and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and identified three loci newly associated with risk: two loci associated with all EOC subtypes at 8q21 (rs11782652, P = 5.5 × 10(-9)) and 10p12 (rs1243180, P = 1.8 × 10(-8)) and another locus specific to the serous subtype at 17q12 (rs757210, P = 8.1 × 10(-10)). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility and implicated CHMP4C in the pathogenesis of ovarian cancer.
ISSN: 1061-4036
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science