ITEM METADATA RECORD
Title: Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31
Authors: Permuth-Wey, Jennifer ×
Lawrenson, Kate
Shen, Howard C
Velkova, Aneliya
Tyrer, Jonathan P
Chen, Zhihua
Lin, Hui-Yi
Ann Chen, Y
Tsai, Ya-Yu
Qu, Xiaotao
Ramus, Susan J
Karevan, Rod
Lee, Janet
Lee, Nathan
Larson, Melissa C
Aben, Katja K
Anton-Culver, Hoda
Antonenkova, Natalia
Antoniou, Antonis C
Armasu, Sebastian M
stralian Cancer Study
stralian Ovarian Cancer Study
Bacot, François
Baglietto, Laura
Bandera, Elisa V
Barnholtz-Sloan, Jill
Beckmann, Matthias W
Birrer, Michael J
Bloom, Greg
Bogdanova, Natalia
Brinton, Louise A
Brooks-Wilson, Angela
Brown, Robert
Butzow, Ralf
Cai, Qiuyin
Campbell, Ian
Chang-Claude, Jenny
Chanock, Stephen
Chenevix-Trench, Georgia
Cheng, Jin Q
Cicek, Mine S
Coetzee, Gerhard A
Consortium of Investigators of Modifiers of BRCA1/2
Cook, Linda S
Couch, Fergus J
Cramer, Daniel W
Cunningham, Julie M
Dansonka-Mieszkowska, Agnieszka
Despierre, Evelyn
Doherty, Jennifer A
Dörk, Thilo
du Bois, Andreas
Dürst, Matthias
Easton, Douglas F
Eccles, Diana
Edwards, Robert
Ekici, Arif B
Fasching, Peter A
Fenstermacher, David A
Flanagan, James M
Garcia-Closas, Montserrat
Gentry-Maharaj, Aleksandra
Giles, Graham G
Glasspool, Rosalind M
Gonzalez-Bosquet, Jesus
Goodman, Marc T
Gore, Martin
Górski, Bohdan
Gronwald, Jacek
Hall, Per
Halle, Mari K
Harter, Philipp
Heitz, Florian
Hillemanns, Peter
Hoatlin, Maureen
Høgdall, Claus K
Høgdall, Estrid
Hosono, Satoyo
Jakubowska, Anna
Jensen, Allan
Jim, Heather
Kalli, Kimberly R
Karlan, Beth Y
Kaye, Stanley B
Kelemen, Linda E
Kiemeney, Lambertus A
Kikkawa, Fumitaka
Konecny, Gottfried E
Krakstad, Camilla
Krüger Kjaer, Susanne
Kupryjanczyk, Jolanta
Lambrechts, Diether
Lambrechts, Sandrina
Lancaster, Johnathan M
Le, Nhu D
Leminen, Arto
Levine, Douglas A
Liang, Dong
Kiong Lim, Boon
Lin, Jie
Lissowska, Jolanta
Lu, Karen H
Lubiński, Jan
Lurie, Galina
Massuger, Leon F A G
Matsuo, Keitaro
McGuire, Valerie
McLaughlin, John R
Menon, Usha
Modugno, Francesmary
Moysich, Kirsten B
Nakanishi, Toru
Narod, Steven A
Nedergaard, Lotte
Ness, Roberta B
Nevanlinna, Heli
Nickels, Stefan
Noushmehr, Houtan
Odunsi, Kunle
Olson, Sara H
Orlow, Irene
Paul, James
Pearce, Celeste L
Pejovic, Tanja
Pelttari, Liisa M
Pike, Malcolm C
Poole, Elizabeth M
Raska, Paola
Renner, Stefan P
Risch, Harvey A
Rodriguez-Rodriguez, Lorna
Anne Rossing, Mary
Rudolph, Anja
Runnebaum, Ingo B
Rzepecka, Iwona K
Salvesen, Helga B
Schwaab, Ira
Severi, Gianluca
Shridhar, Viji
Shu, Xiao-Ou
Shvetsov, Yurii B
Sieh, Weiva
Song, Honglin
Southey, Melissa C
Spiewankiewicz, Beata
Stram, Daniel
Sutphen, Rebecca
Teo, Soo-Hwang
Terry, Kathryn L
Tessier, Daniel C
Thompson, Pamela J
Tworoger, Shelley S
van Altena, Anne M
Vergote, Ignace
Vierkant, Robert A
Vincent, Daniel
Vitonis, Allison F
Wang-Gohrke, Shan
Palmieri Weber, Rachel
Wentzensen, Nicolas
Whittemore, Alice S
Wik, Elisabeth
Wilkens, Lynne R
Winterhoff, Boris
Ling Woo, Yin
Wu, Anna H
Xiang, Yong-Bing
Yang, Hannah P
Zheng, Wei
Ziogas, Argyrios
Zulkifli, Famida
Phelan, Catherine M
Iversen, Edwin
Schildkraut, Joellen M
Berchuck, Andrew
Fridley, Brooke L
Goode, Ellen L
Pharoah, Paul D P
Monteiro, Alvaro N A
Sellers, Thomas A
Gayther, Simon A #
Issue Date: Mar-2013
Series Title: Nature Communications vol:4 pages:1627
Article number: 10.1038/ncomms2613
Abstract: Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3' untranslated region at putative microRNA (miRNA)-binding sites represent functional targets that influence EOC susceptibility. Here, we evaluate the association between 767 miRNA-related single-nucleotide polymorphisms (miRSNPs) and EOC risk in 18,174 EOC cases and 26,134 controls from 43 studies genotyped through the Collaborative Oncological Gene-environment Study. We identify several miRSNPs associated with invasive serous EOC risk (odds ratio=1.12, P=10(-8)) mapping to an inversion polymorphism at 17q21.31. Additional genotyping of non-miRSNPs at 17q21.31 reveals stronger signals outside the inversion (P=10(-10)). Variation at 17q21.31 is associated with neurological diseases, and our collaboration is the first to report an association with EOC susceptibility. An integrated molecular analysis in this region provides evidence for ARHGAP27 and PLEKHM1 as candidate EOC susceptibility genes.
ISSN: 2041-1723
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science