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Title: Genetic and environmental influences on blood pressure variability: a study in twins
Authors: Xu, Xiaojing ×
Ding, Xiuhua
Zhang, Xinyan
Su, Shaoyong
Treiber, Frank A
Vlietinck, Robert
Fagard, Robert
Derom, Cathérine
Gielen, Marij
Loos, Ruth
Snieder, Harold
Wang, Xiaoling #
Issue Date: Apr-2013
Publisher: Gower Medical Pub.
Series Title: Journal of Hypertension vol:31 issue:4 pages:690-697
Abstract: OBJECTIVES:: Blood pressure variability (BPV) and its reduction in response to antihypertensive treatment are predictors of clinical outcomes; however, little is known about its heritability. In this study, we examined the relative influence of genetic and environmental sources of variance of BPV and the extent to which it may depend on race or sex in young twins. METHODS:: Twins were enrolled from two studies. One study included 703 white twins (308 pairs and 87 singletons) aged 18-34 years, whereas another study included 242 white twins (108 pairs and 26 singletons) and 188 black twins (79 pairs and 30 singletons) aged 12-30 years. BPV was calculated from 24-h ambulatory blood pressure recording. RESULTS:: Twin modeling showed similar results in the separate analysis in both twin studies and in the meta-analysis. Familial aggregation was identified for SBP variability (SBPV) and DBP variability (DBPV) with genetic factors and common environmental factors together accounting for 18-40% and 23-31% of the total variance of SBPV and DBPV, respectively. Unique environmental factors were the largest contributor explaining up to 82-77% of the total variance of SBPV and DBPV. No sex or race difference in BPV variance components was observed. The results remained the same after adjustment for 24-h blood pressure levels. CONCLUSIONS:: The variance in BPV is predominantly determined by unique environment in youth and young adults, although familial aggregation due to additive genetic and/or common environment influences was also identified explaining about 25% of the variance in BPV.
ISSN: 0263-6352
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Clinical Genetics
Physical Activity, Sports & Health Research Group
× corresponding author
# (joint) last author

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