Title: Analysis of Over 10,000 Cases Finds No Association between Previously-Reported Candidate Polymorphisms and Ovarian Cancer Outcome
Authors: White, Kristin L ×
Vierkant, Robert A
Fogarty, Zachary
Charbonneau, Bridget
Block, Matthew S
Pharoah, Paul D P
Chenevix-Trench, Georgia
Rossing, Mary Anne
Cramer, Daniel W
Pearce, Leigh
Schildkraut, Joellen M
Menon, Usha
Kruger Kjær, Susanne
Levine, Douglas A
Gronwald, Jacek
Anton-Culver, Hoda
Whittemore, Alice S
Karlan, Beth Y
Lambrechts, Diether
Wentzensen, Nicolas
Kupryjanczyk, Jolanta
Chang-Claude, Jenny
Bandera, Elisa V
Hogdall, Estrid V
Heitz, Florian
Kaye, Stan
Fasching, Peter A
Campbell, Ian G
Goodman, Marc T
Pejovic, Tanja
Bean, Yukie T
Lurie, Galina
Eccles, Diana
Hein, Alexander
Beckmann, Matthias W
Ekici, Arif B
Paul, James
Brown, Robert
Flanagan, James M
Harter, Philipp
du Bois, Andreas
Schwaab, Ira
Hogdall, Claus K
Lundvall, Lene
Olson, Sara H
Orlow, Irene
Paddock, Lisa E
Rudolph, Anja
Eilber, Ursula
Dansonka-Mieszkowska, Agnieszka
Rzepecka, Iwona K
Ziolkowska-Seta, Izabela
Brinton, Louise A
Yang, Hannah P
Garcia-Closas, Montserrat
Despierre, Evelyn
Lambrechts, Sandrina
Vergote, Ignace
Walsh, Christine
Lester, Jenny
Sieh, Weiva
McGuire, Valerie
Rothstein, Joseph H
Ziogas, Argyrios
Lubinski, Jan
Cybulski, Cezary
Menkiszak, Janusz
Jensen, Allan
Gayther, Simon A
Ramus, Susan J
Gentry-Maharaj, Aleksandra
Berchuck, Andrew
Wu, Anna H
Pike, Malcolm C
Van Den Berg, David
Terry, Kathryn L
Vitonis, Allison F
Doherty, Jennifer A
Johnatty, Sharon E
Defazio, Anna
Song, Honglin
Tyrer, Jonathan
Sellers, Thomas A
Phelan, Catherine M
Kalli, Kimberly R
Cunningham, Julie M
Fridley, Brooke L
Goode, Ellen L #
Issue Date: May-2013
Publisher: American Association for Cancer Research
Series Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology vol:22 issue:5 pages:987-92
Abstract: BACKGROUND: Ovarian cancer is a leading cause of cancer-related death among women. In an effort to understand contributors to disease outcome, we evaluated single-nucleotide polymorphisms (SNPs) previously associated with ovarian cancer recurrence or survival, specifically in angiogenesis, inflammation, mitosis, and drug disposition genes. METHODS: Twenty-seven SNPs in VHL, HGF, IL18, PRKACB, ABCB1, CYP2C8, ERCC2, and ERCC1 previously associated with ovarian cancer outcome were genotyped in 10,084 invasive cases from 28 studies from the Ovarian Cancer Association Consortium with over 37,000 observed person-years and 4,478 deaths. Cox proportional hazards models were used to examine the association between candidate SNPs and ovarian cancer recurrence or survival with and without adjustment for key covariates. RESULTS: We observed no association between genotype and ovarian cancer recurrence or survival for any of the SNPs examined. CONCLUSIONS: These results refute prior associations between these SNPs and ovarian cancer outcome and underscore the importance of maximally powered genetic association studies. Impact: These variants should not be used in prognostic models. Alternate approaches to uncovering inherited prognostic factors, if they exist, are needed.
ISSN: 1055-9965
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Translational Genetics (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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