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Title: Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts
Authors: Vasen, Hans F A ×
Blanco, Ignacio
Aktan-Collan, Katja
Gopie, Jessica P
Alonso, Angel
Aretz, Stefan
Bernstein, Inge
Bertario, Lucio
Burn, John
Capella, Gabriel
Colas, Chrystelle
Engel, Christoph
Frayling, Ian M
Genuardi, Maurizio
Heinimann, Karl
Hes, Frederik J
Hodgson, Shirley V
Karagiannis, John A
Lalloo, Fiona
Lindblom, Annika
Mecklin, Jukka-Pekka
Møller, Pal
Myrhoj, Torben
Nagengast, Fokko M
Parc, Yann
Ponz de Leon, Maurizio
Renkonen-Sinisalo, Laura
Sampson, Julian R
Stormorken, Astrid
Sijmons, Rolf H
Tejpar, Sabine
Thomas, Huw J W
Rahner, Nils
Wijnen, Juul T
Järvinen, Heikki Juhani
Möslein, Gabriela
(the Mallorca group) #
Issue Date: Jun-2013
Publisher: BMJ Publishing Group
Series Title: Gut vol:62 issue:6 pages:812-23
Abstract: Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. In 2007, a group of European experts (the Mallorca group) published guidelines for the clinical management of LS. Since then substantial new information has become available necessitating an update of the guidelines. In 2011 and 2012 workshops were organised in Palma de Mallorca. A total of 35 specialists from 13 countries participated in the meetings. The first step was to formulate important clinical questions. Then a systematic literature search was performed using the Pubmed database and manual searches of relevant articles. During the workshops the outcome of the literature search was discussed in detail. The guidelines described in this paper may be helpful for the appropriate management of families with LS. Prospective controlled studies should be undertaken to improve further the care of these families.
URI: 
ISSN: 0017-5749
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Digestive Oncology (+)
× corresponding author
# (joint) last author

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