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Title: Treg infiltration in glioma: a hurdle for antiglioma immunotherapy
Authors: Vandenberk, Lien ×
Van Gool, Stefaan #
Issue Date: 2012
Publisher: Future Medicine Ltd.
Series Title: Immunotherapy vol:4 issue:7 pages:675-678
Abstract: Tregs play a crucial role in glioma-mediated immunosuppression; hence, tackling the Treg population in patients with malignant glioma could improve the clinical success rate of antiglioma immunotherapy. Therefore, it is of high importance to elucidate the mechanisms responsible for Treg recruitment and retention within the glioma microenvironment. The current paper demonstrates that, in addition to preferential chemoattraction, glioma-derived soluble factors can also induce preferential Treg proliferation and survival. These data identify new targets for Treg modulating strategies.
ISSN: 1750-743X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Microbiology & Immunology - miscellaneous
Laboratory of Pediatric Immunology
× corresponding author
# (joint) last author

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