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Title: Cross-species behavioural genetics: A starting point for unravelling the neurobiology of human psychiatric disorders
Authors: de Mooij-van Malsen, Annetrude J G ×
Vinkers, Christiaan H
Peterse, Danielle P
Olivier, Berend
Kas, Martien J H #
Issue Date: Aug-2011
Publisher: Pergamon
Series Title: Progress in Neuro-Psychopharmacology & Biological Psychiatry vol:35 issue:6 pages:1383-90
Article number: 10.1016/j.pnpbp.2010.10.003
Abstract: Identifying the genetic and neurobiological mechanisms underlying certain behavioural traits is an important strategy to understand the aetiology of various psychiatric disorders and to find potential new treatment possibilities. It has proven a great challenge to develop paradigms that allow translational research for behavioural phenotypes that are relevant for disorders across the psychiatric spectrum. Recently, there has been increasing attention for studies that implement rodent behavioural paradigms in the home cage to assess the association between genetic backgrounds and behavioural traits. The application of interspecies genetics to unravel these traits has revealed novel insights in the genetic mechanisms that are encoding phenotypes relevant to biological processes underlying psychiatric disorders. By means of two examples, namely the stress-induced hyperthermia paradigm and the home cage environment, this review aims to show that by using individual genetic variations with phenotypes obtained from mice and across categories of neuropsychiatric disorders, novel insights in the neurobiological trajectory of psychiatric disorders can be obtained.
URI: 
ISSN: 0278-5846
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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