Title: Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury
Authors: Hofstra, Jorrit J ×
Cornet, Alexander D
Declerck, Paul
Dixon, Barry
Aslami, Hamid
Vlaar, Alexander P J
Roelofs, Joris J
van der Poll, Tom
Levi, Marcel
Schultz, Marcus J #
Issue Date: 2013
Publisher: Public Library of Sciene
Series Title: PLoS One vol:8 issue:2 pages:e55262
Article number: 10.1371/journal.pone.0055262
Abstract: Critically ill patients frequently develop acute lung injury (ALI). Disturbed alveolar fibrin turnover, a characteristic feature of ALI, is the result of both activation of coagulation and inhibition of fibrinolysis. Nebulized fibrinolytic agents could exert lung-protective effects, via promotion of fibrinolysis as well as anti-inflammation.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Pharmaceutical Biology (-)
× corresponding author
# (joint) last author

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