Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury
Hofstra, Jorrit J × Cornet, Alexander D Declerck, Paul Dixon, Barry Aslami, Hamid Vlaar, Alexander P J Roelofs, Joris J van der Poll, Tom Levi, Marcel Schultz, Marcus J #
Public Library of Sciene
PLoS One vol:8 issue:2 pages:e55262
Critically ill patients frequently develop acute lung injury (ALI). Disturbed alveolar fibrin turnover, a characteristic feature of ALI, is the result of both activation of coagulation and inhibition of fibrinolysis. Nebulized fibrinolytic agents could exert lung-protective effects, via promotion of fibrinolysis as well as anti-inflammation.