Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments
Ivarsson, Ylva * Anna Maria Wawrzyniak, Anna * Kashyap, Rudra Polanowska, Jolanta Betzi, Stéphane Lembo, Frédérique Vermeiren, Elke Chiheb, Driss Lenfant, Nicolas Morelli, Xavier Borg, Jean-Paul Reboul, Jérôme Zimmermann, Pascale # ×
Public Library of Sciene
PLoS One vol:8 issue:2 pages:e54581
PDZ domains are highly abundant protein-protein interaction modules involved in the wiring of protein networks. Emerging evidence indicates that some PDZ domains also interact with phosphoinositides (PtdInsPs), important regulators of cell polarization and signaling. Yet our knowledge on the prevalence, specificity, affinity, and molecular determinants of PDZ-PtdInsPs interactions and on their impact on PDZ-protein interactions is very limited.