Title: Cysteamine: an old drug with new potential
Authors: Besouw, Martine ×
Masereeuw, Rosalinde
van den Heuvel, Bert
Levtchenko, Elena #
Issue Date: Aug-2013
Publisher: Elsevier Science Ltd.
Series Title: Drug discovery today vol:18 issue:15-16 pages:785-792
Article number: S1359-6446(13)00038-X
Abstract: Cysteamine is an amino thiol with the chemical formula HSCH2CH2NH2. Endogenously, cysteamine is derived from coenzyme A degradation, although its plasma concentrations are low. Most experience with cysteamine as a drug originates from the field of the orphan disease cystinosis, in which cysteamine is prescribed to decrease intralysosomal cystine accumulation. However, over the years, the drug has been used for several other applications both in vitro and in vivo. In this article, we review the different applications of cysteamine, ending with an overview of ongoing clinical trials for new indications, such as neurodegenerative disorders and nonalcoholic fatty liver disease (NAFLD). The recent development of an enteric-coated cysteamine formulation makes cysteamine more patient friendly and will extend its applicability for both old and new indications.
ISSN: 1359-6446
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Growth, Proliferation, Child and Adolescent (-)
× corresponding author
# (joint) last author

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