Title: Immunogenic cell death and DAMPs in cancer therapy
Authors: Krysko, Dmitri V *
GARG, Abhishek *
Kaczmarek, Agnieszka
Krysko, Olga
Agostinis, Patrizia
Vandenabeele, Peter # ×
Issue Date: Dec-2012
Publisher: Nature Pub. Group
Series Title: Nature Reviews. Cancer vol:12 issue:12 pages:860-75
Article number: 10.1038/nrc3380
Abstract: Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent death that did not trigger an immune response, in recent years a new concept of immunogenic cell death (ICD) has emerged. The immunogenic characteristics of ICD are mainly mediated by damage-associated molecular patterns (DAMPs), which include surface-exposed calreticulin (CRT), secreted ATP and released high mobility group protein B1 (HMGB1). Most DAMPs can be recognized by pattern recognition receptors (PRRs). In this Review, we discuss the role of endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in regulating the immunogenicity of dying cancer cells and the effect of therapy-resistant cancer microevolution on ICD.
ISSN: 1474-175X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Cell Death Research & Therapy
* (joint) first author
× corresponding author
# (joint) last author

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