Title: Inducers of immunogenic cancer cell death
Authors: Dudek, Aleksandra
GARG, Abhishek
Krysko, Dmitri V
De Ruysscher, Dirk
Agostinis, Patrizia # ×
Issue Date: Aug-2013
Publisher: Elsevier Science
Series Title: Cytokine & Growth Factor Reviews vol:24 issue:4 pages:319-33
Article number: S1359-6101(13)00006-3
Abstract: Recently, cytokine-based pro-tumourigenic signalling has been found to play a major role in the immune system's pro-tumourigenic activity. On the other hand, other recent findings have shown that immunogenic cancer cell death triggered by certain anticancer modalities might reset the dysfunctional immune system towards the activation of a long-lasting protective anti-tumour response. Therefore, using inducers of immunogenic cell death (ICD) that can prevent or impede tumour-promoting cytokine signalling is one of the best ways of instigating or restoring efficient anti-tumour immunity. In this review it is discussed, how the different ICD inducers interact with the immune system and influence cytokine-based pro-tumourigenic signalling. We believe that it is crucial to discover or develop new anti-cancer therapeutic modalities that can induce ICD and impede tumour-promoting cytokine signalling.
ISSN: 1359-6101
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Cell Death Research & Therapy
× corresponding author
# (joint) last author

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