Title: Clinicopathological characteristics of Posttransplant Lymphoproliferative Disorders of T-cell origin: single center series of 9 cases and meta-analysis of 147 reported cases
Authors: Herreman, An * ×
Dierickx, Daan *
Morscio, Julie
Camps, Jordi
Bittoun, Emilie
Verhoef, Gregor
De Wolf-Peeters, Christiane
Sagaert, Xavier
Tousseyn, Thomas #
Issue Date: 13-Feb-2013
Publisher: Harwood Academic Publishers
Series Title: Leukemia & Lymphoma vol:54 issue:10 pages:2190-2199
Abstract: Abstract T-cell or natural killer (NK)-cell posttransplant lymphoproliferative disorder (T-PTLD) is a rare but severe complication after transplantation. Here we present the clinicopathological features of a single center series of 9 cases. Additionally, we summarize the clinicopathological findings of 147 T/NK-cell PTLDs reported in the literature in an attempt to define subtype-specific characteristics. T/NK-cell PTLD occurs in patients of all ages, usually extranodally, and most frequently after kidney transplantation. Organ specific incidence however is highest following heart transplantation. Approximately one third of T-cell PTLDs are Epstein-Barr virus (EBV)-related, with peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) being the most prevalent EBV-associated T-cell PTLD. A male predominance was observed, which is most striking in the EBV (+) group, particularly in PTCL, NOS. With a median posttransplantation interval of 72 months T-cell PTLDs are among the late occurring PTLDs. Of the most common T-cell PTLDs, anaplastic large cell lymphoma (ALCL) has the best prognosis, whereas PTCL, NOS and hepatosplenic T-cell lymphoma (HSTCL) have the worst prognosis. EBV (+) cases seem to have a longer survival than EBV (-) cases, suggesting a different pathogenetic mechanism.
ISSN: 1042-8194
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Department of Development and Regeneration - miscellaneous (+)
Laboratory of Molecular Biology of Leukemia
Cell and Gene Therapy Applications (-)
* (joint) first author
× corresponding author
# (joint) last author

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