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Title: Dopaminergic reward signals selectively decrease fMRI activity in primate visual cortex
Authors: Arsenault, John
Nelissen, Koen
Jarraya, Bechir
Vanduffel, Wim # ×
Issue Date: 20-Mar-2013
Publisher: Cell Press
Series Title: Neuron vol:77 issue:6 pages:1174-1186
Abstract: Stimulus-reward coupling without attention can induce highly specific perceptual learning effects, suggesting that reward triggers elective plasticity within visual cortex. Additionally, dopamine-releasing events—temporally surrounding stimulus-reward associations—selectively enhance memory. These forms of plasticity may be evoked by selective modulation of stimulus representations during dopamineinducing events. However, it remains to be shown whether dopaminergic signals can selectively modulate visual cortical activity.Wemeasured fMRI activity in monkey visual cortex during reward-only trials apart from intermixed cue-reward trials. Reward without visual stimulation selectively decreased fMRI activity within the cue representations that had been paired with reward during other trials. Behavioral tests indicated that these same uncued reward trials strengthened cue-reward associations. Furthermore, such spatially-specific activity modulations depended on prediction error, as shown by manipulations of reward magnitude, cue-reward probability, cue-reward familiarity, and dopamine signaling. This cue-selective negative reward signal offers a mechanism for selectively gating sensory cortical plasticity.
ISSN: 0896-6273
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Neurophysiology
Laboratory for Neuro- and Psychofysiology
× corresponding author
# (joint) last author

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