Title: Declining prevalence of HIV-1 drug resistance in antiretroviral treatment-exposed individuals in Western Europe
Authors: De Luca, Andrea ×
Dunn, David
Zazzi, Maurizio
Camacho, Ricardo
Torti, Carlo
Fanti, Iuri
Kaiser, Rolf
Sönnerborg, Anders
Codoñer, Francisco M
Van Laethem, Kristel
Vandamme, Anne-Mieke
Bansi, Loveleen
Ghisetti, Valeria
van de Vijver, David A M C
Asboe, David
Prosperi, Mattia C F
Di Giambenedetto, Simona
for the SEHERE collaboration in Chain #
Issue Date: Apr-2013
Publisher: Published by the University of Chicago Press for the Infectious Diseases Society of America
Series Title: The Journal of infectious diseases vol:207 issue:8 pages:1216-1220
Abstract: HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis.
ISSN: 0022-1899
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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