Title: HIV-1 Subtype Is an Independent Predictor of Reverse Transcriptase Mutation K65R in HIV-1 Patients Treated with Combination Antiretroviral Therapy Including Tenofovir
Authors: Theys, Kristof ×
Vercauteren, Jurgen
Snoeck, Joke
Zazzi, M
Camacho, R J
Torti, C
Schülter, E
Clotet, B
Sönnerborg, A
De Luca, A
Grossman, Z
Struck, D
Vandamme, Anne-Mieke
Abecasis, A B #
Issue Date: Feb-2013
Publisher: American Society for Microbiology (ASM)
Series Title: Antimicrobial Agents and Chemotherapy vol:57 issue:2 pages:1053-6
Article number: 10.1128/AAC.01668-12
Abstract: Subtype-dependent selection of HIV-1 reverse transcriptase resistance mutation K65R was previously observed in cell culture and small clinical investigations. We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specific K65R pathways.
ISSN: 0066-4804
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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