Title: A safety study on single intravenous dose of tetrachloro-diphenyl glycoluril [iodogen] dissolved in dimethyl sulphoxide (DMSO)
Authors: Miranda Cona, Marlein
Li, Junjie
Chen, Feng
Feng, YUanbo
Aguiar Alpizar, Yeranddy
Vanstapel, Florent
Talavera PĂ©rez, Karel
de Witte, Peter
Verbruggen, Alfons
Sun, Zipping
Oyen, Raymond
Ni, Yicheng # ×
Issue Date: Aug-2013
Publisher: Taylor & Francis
Series Title: Xenobiotica vol:43 issue:8 pages:730-737
Abstract: Abstract 1. Iodogen (tetrachloro-diphenyl glycoluril) dissolved in DMSO (dimethyl sulphoxide) appears indispensable in radioiodination of hypericin for a new anticancer strategy. We studied the safety of intravenously administered iodogen/DMSO in mice (n = 132). 2. Median lethal dose (LD(50)) of iodogen/DMSO was determined with doses of 40.0, 50.0, 55.0, 60.0, 65.0 and 70.0 mg/kg. Next, toxicity of iodogen/DMSO at 30.0 mg/kg was evaluated using saline and DMSO as controls. Changes in behaviour, body weight and serum biochemistry were evaluated. Histopathology of lungs, heart, liver and kidney was performed. 3. LD(50) values of iodogen/DMSO were 59.5 mg/kg (95% confidence limits (CI): 54.1-65.4 mg/kg) and 61.0 mg/kg (95%CI: 56.2-66.2 mg/kg) for female and male mice, respectively. Similar to that of control groups, no animal deaths were encountered after iodogen/DMSO administration at 30.0 mg/kg. Body weights over 24 h were not altered in all groups, but significantly higher in iodogen/DMSO and DMSO groups (p < 0.05) 14 d post-injection. Blood urea nitrogen and alkaline phosphatase increased (p < 0.05) in iodogen/DMSO group without clinical symptoms. No pathologies were found by gross and microscopic inspection. 4. A single dose of iodogen/DMSO up to 30.0 mg/kg, over 3000 times the dose in potential human applications, appears safe, with an LD(50) doubling that dose in mice.
ISSN: 0049-8254
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biomedical Quality Assurance Research Unit
Laboratory of Ion Channel Research
Theragnostic Laboratory (+)
× corresponding author
# (joint) last author

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