Title: Single-center analysis of biopsy-confirmed posttransplant lymphoproliferative disorder: incidence, clinico-pathological characteristics and prognostic factors
Authors: Dierickx, Daan * ×
Tousseyn, Thomas *
Sagaert, Xavier
Fieuws, Steffen
Wlodarska, Iwona
Morscio, Julie
Brepoels, Lieselot
Kuypers, Dirk
Vanhaecke, Johan
Nevens, Frederik
Verleden, Geert
van damme-lombaerts, Rita
Renard, Marleen
Pirenne, Jacques
De Wolf-Peeters, Chris
Verhoef, Gregor #
Issue Date: 27-Feb-2013
Publisher: Harwood Academic Publishers
Series Title: Leukemia & Lymphoma vol:54 issue:11 pages:2433-2440
Abstract: Abstract Hematopoietic stem cell and solid organ transplant recipients diagnosed with biopsy-confirmed posttransplant lymphoproliferative disorder (PTLD) at our institution from 1989 to 2010 were identified. Patient-, transplantation- and disease-related characteristics, prognostic factors and outcome were collected and analyzed. One hundred-forty biopsy-proven PTLD cases were included. Overall incidence in the transplant population was 2.12% with heart transplant recipients carrying the highest risk. Most PTLDs were monomorphic (83.6%) with diffuse large B cell lymphoma being the most frequent subtype. The majority of cases (70.7%) occurred > 1 year posttransplantation, whereas 66% were Epstein Barr virus positive. Following initial therapy overall response rate was 68.5%. Three-year relapse-free and overall survival were 59% and 49%, respectively. At last follow-up 44% of the patients were alive. Multivariable analysis identified several classical lymphoma-specific poor prognostic factors for the different outcome measures. The value of the International Prognostic Index was confirmed in our analysis.
ISSN: 1042-8194
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Translational Cell & Tissue Research
Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat)
* (joint) first author
× corresponding author
# (joint) last author

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