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Title: FKBP5 as a possible moderator of the psychosis-inducing effects of childhood trauma
Authors: Collip, Dina ×
Myin-Germeys, Inez
Wichers, Marieke
Jacobs, Nele
Derom, Cathérine
Thiery, Evert
Lataster, Tineke
Simons, Claudia
Delespaul, Philippe
Marcelis, Machteld
van Os, Jim
van Winkel, Ruud #
Issue Date: Apr-2013
Publisher: Royal Medico-Psychological Association
Series Title: British Journal of Psychiatry vol:202 pages:261-268
Abstract: BACKGROUND: FK506 binding protein 5 (FKBP5) has repeatedly been shown to be a critical determinant of post-traumatic stress disorder (PTSD) and depression following childhood trauma. AIMS: To examine the role of FKBP5-trauma interactions in the partly stress-related psychosis phenotype. METHOD: In 401 general population twins, four functional polymorphisms were examined in models of psychosis and cortisol, and followed up in models of psychosis in three samples at different familial liability (175 controls, 200 unaffected siblings and 195 patients with a psychotic disorder). RESULTS: The most consistent finding was an interaction between childhood trauma and rs9296158/rs4713916 on psychotic symptoms and cortisol in the twin sample, combined with a directionally similar interaction in siblings (rs4713916) and patients (rs9296158), A-allele carriers at both polymorphisms being most vulnerable to trauma. CONCLUSIONS: Trauma may increase the risk of psychosis through enduring changes in the cortisol feedback loop, similar to that for PTSD, suggesting comparable biological mechanisms for psychosis across diagnostic boundaries.
URI: 
ISSN: 0007-1250
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Clinical Genetics
× corresponding author
# (joint) last author

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